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Terry W. Moore, Ph.D.Terry Moore

Assistant Professor
Department of Medicinal Chemistry and Pharmacognosy

University of Illinois at Chicago
College of Pharmacy
833 South Wood Street (M/C 781)
Chicago IL 60612-7231

Office: 504B PHARM
Office Phone: 312.413.1846
Lab: 504 PHARM
Lab Phone: 312.355.2773
E-mail address: twmoore@uic.edu
Website:http://moorelab.publish.uic.edu

Education:

Emory University, Atlanta, GA, Post-Doctoral Fellow 2009-2013
University of Illinois at Urbana-Champaign, Urbana-Champaign, IL, Ph.D. 2003-2008

Research Interests:

Our research group is interested in inhibiting protein-protein interactions implicated in the progression of certain types of cancer, particularly hormone-responsive and -refractory cancers.  Specifically, we are interested in inhibiting the Nrf2/Keap1 interaction, an interaction involved in various disease states because of Nrf2’s central role in regulating the cell’s response to reactive species. The second project is focused on inhibiting the interactions of nuclear receptors with coactivators. We study these interactions using fluorescence-based assays, and the lab uses the tools of synthetic medicinal chemistry to develop both small molecule- and peptide-based inhibitors.

Selected Publications (from __ total):

  1. Brown A, Shi Q, Moore TW, Yoon Y, Prussia A, Maddox C, Liotta DC, Shim H, Snyder JP. Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties. J Med Chem. 2013 May 9;56(9):3456-66. doi: 10.1021/jm4002692. Epub 2013 Apr 23. PubMed PMID: 23550937. [abstract]
  2. Moore TW, Sana K, Yan D, Thepchatri P, Ndungu JM, Saindane MT, Lockwood MA, Natchus MG, Liotta DC, Plemper RK, Snyder JP, Sun A. Asymmetric synthesis of host-directed inhibitors of myxoviruses. Beilstein J Org Chem. 2013;9:197-203. doi: 10.3762/bjoc.9.23. Epub 2013 Jan 30. PubMed PMID: 23400228; PubMed Central PMCID: PMC3566758. [abstract]
  3. Yamaguchi M, Moore TW, Sun A, Snyder JP, Shoji M. Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis: involvement in Smad activation and NF-?B inhibition. Integr Biol (Camb). 2012 Aug;4(8):905-13. doi: 10.1039/c2ib20045g. Epub 2012 Jul 3. PubMed PMID: 22751853. [abstract]
  4. Zhu S, Moore TW, Lin X, Morii N, Mancini A, Howard RB, Culver D, Arrendale RF, Reddy P, Evers TJ, Zhang H, Sica G, Chen ZG, Sun A, Fu H, Khuri FR, Shin DM, Snyder JP, Shoji M. Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts. Integr Biol (Camb). 2012 Jun;4(6):633-40. doi: 10.1039/c2ib20007d. Epub 2012 Apr 25. PubMed PMID: 22532032. [abstract]
  5. Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC, Snyder JP, Yoon Y, Shim H, Marcus AI, Miller AH, Pace TW. Inhibition of the NF-?B signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Int Immunopharmacol. 2012 Feb;12(2):368-77. doi: 10.1016/j.intimp.2011.12.009. Epub 2011 Dec 22. PubMed
    PMID: 22197802; PubMed Central PMCID: PMC3372981. [abstract]
  6. Sun A, Moore TW, Gunther JR, Kim MS, Rhoden E, Du Y, Fu H, Snyder JP, Katzenellenbogen JA. Discovering small-molecule estrogen receptor a/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency. ChemMedChem. 2011 Apr 4;6(4):654-66. doi: 10.1002/cmdc.201000507. Epub 2011 Mar 1. PubMed PMID: 21365764; PubMed Central PMCID: PMC3177402. [abstract]
  7. Moore TW, Gunther JR, Katzenellenbogen JA. Probing the topological tolerance of multimeric protein interactions: evaluation of an estrogen/synthetic ligand for FK506 binding protein conjugate. Bioconjug Chem. 2010 Oct 20;21(10):1880-9. doi: 10.1021/bc100266v. PubMed PMID: 20919698; PubMed Central PMCID: PMC2967433. [abstract]
  8. Moore TW, Mayne CG, Katzenellenbogen JA. Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs). Mol Endocrinol. 2010 Apr;24(4):683-95. doi: 10.1210/me.2009-0362. Epub 2009 Nov 20. Review. PubMed PMID: 19933380; PubMed Central PMCID: PMC2852352. [abstract]
  9. Gunther JR, Du Y, Rhoden E, Lewis I, Revennaugh B, Moore TW, Kim SH, Dingledine R, Fu H, Katzenellenbogen JA. A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator binding. J Biomol Screen. 2009 Feb;14(2):181-93. doi: 10.1177/1087057108329349. Epub 2009 Feb 4. PubMed PMID: 19196699; PubMed Central PMCID: PMC2731238. [abstract]
  10. Gunther JR, Moore TW, Collins ML, Katzenellenbogen JA. Amphipathic benzenes are designed inhibitors of the estrogen receptor alpha/steroid receptor coactivator interaction. ACS Chem Biol. 2008 May 16;3(5):282-6. doi: 10.1021/cb800056r. PubMed PMID: 18484708; PubMed Central PMCID: PMC2427189. [abstract]

 

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