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Chun-Tao Che, Ph.D.Joanna Burdette

Norman R. Farnsworth Professor of Pharmacognosy
Department of Medicinal Chemistry and Pharmacognosy

University of Illinois at Chicago
College of Pharmacy
833 South Wood Street (M/C 781)
Chicago IL 60612-7231

Office: 323 PHARM
Office Phone: 312-996-5234
Lab: 274/294 PHARM
Fax Number: 312-996-7107
E-mail address: chect@uic.edu
Website: https://sites.google.com/site/whoictm/participants/che

Education:

The Chinese University of Hong Kong, B.Sc. (Biology), 1975
The Chinese University of Hong Kong, M.Phil. (Biochemistry), 1977
The University of Illinois at Chicago, Ph.D. (Pharmacognosy), 1982

Previous Positions Held:

Postdoctoral Chemist, Ludwig Institute for Cancer Research, Toronto, Canada (1982-1984)
Research Associate/Research Assistant Professor, Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago (1984-1991)
Associate Professor, Department of Chemistry, Hong Kong University of Science and Technology (1991-1998)
Professor and Director, School of Chinese Medicine, The Chinese University of Hong Kong (1998-2010)

Research Interests:

Interested in natural drugs and Chinese medicine, including:

  1. Natural products chemistry: isolation, characterization, and structural elucidation of secondary metabolites from medicinal plants and other natural sources
  2. Biologically active natural substances
  3. Chemical/biological standardization and quality assessment of herbal drugs and herb-based preparations
  4. Development of analytical techniques for herbal drug analysis
  5. Development of evidence-based Chinese medicine and other natural products

Publications (since 2012):

  1. Q.Q. Mao, Z. Huang, S.P. Ip, Y.F. Xian and C.T. Che, Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats.Behavioural Brain Res. 227: 305-309, 2012.
  2. Q.Q. Mao, S.P. Ip, Y.F. Xian, Z. Hu and C.T. Che, Antidepressant-like effect of peony: A mini-review. Pharm. Biol. 50:72-77, 2012.
  3. J.M. Yang, P.S.P. Ip, J.C.Y. Wu, L. Lao, H.H.S. Fong, J.J.Y. Sung, B. Berman, J.H.K. Yeung and C.T. Che, Schisandra chinensis reverses visceral hypersensitivity in a neonatal-maternal separated rat model. Phytomedicine 19: 402-408, 2012.
  4. J.M. Yang, S.P. Ip, Y.F. Xian, M. Zhao, Z.X. Lin, J.H.K. Yeung, R.C.Y. Chan, S.S. Lee and C.T. Che, Impact of the herbal medicine Sophora flavescens on the oral pharmacokinetics of indinavir in rats: The involvement of CYP3A and P-glycoprotein. PLoS One, e31312, 2012.
  5. F.W.K. Cheung, J. Guo, Y.H. Ling, C.T. Che and W.K. Liu, Anti-melanogenic property of geoditin A in murine B16 cells. Marine Drugs 10: 465-476, 2012.
  6. Z.H. Yang, V. Grinchuk, S.P. Ip, C.T. Che, H.H.S. Fong, L. Lao, J.C. Wu, J. Sung, B. Berman, T. Shea-Donohue and A. Zhao, Anti-inflammatory activities of a Chinese herbal formula IBS-20 in vitro and in vivo. Evid.-based Complement. Alternat. Med. (eCAM), e491496, 2012.
  7. R. Feng, Y.Y. Zhang, X. Chen, Y. Wang, J.G. Shi, C.T. Che, J.H.K. Yeung, J.Y. Ma, X.S. Tan, C. Yang, Y.L. Deng and Y.K. Zhang, In vitro study on metabolite profiles of bioactive xanthones isolated form Halenia elliptica D. Don by high performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry. J. Pharm. Biomed. Anal. 62: 228-234, 2012.
  8. X.L. Dong, M. Zhao, K.K. Wong, C.T. Che and M.S. Wong, Improvement of Ca balance by Fructus Ligustri Lucidi extract in mature female rats was associated with the induction of serum parathyroid hormone levels. Brit. J. Nutr. 108: 92-101, 2012.
  9. W.K. Liu, Y.H. Ling, F.W.K. Cheung and C.T. Che, Stellettin A induces endoplasmic reticulum stress in murine B16 melanoma cells. J. Nat. Prod. 75: 586-590, 2012.
  10. Q.Q. Mao, Z. Huang, S.P. Ip, Y.F. Xian and C.T. Che, Protective effects of piperine against corticosterone-induced neurotoxicity in PC12 cells. Cell. Mol. Neurobiol. 32: 531-537, 2012.
  11. L.L. Zhou, Z.X. Lin, K.P. Fung, C.T. Che, M. Zhao, C.H.K. Cheng and Z. Zuo, Ethyl acetate fraction of radix Rubiae inhibits cell growth and promotes terminal differentiation in cultured human keratinocytes. J. Ethnopharmacol. 142: 241-247, 2012.
  12. M. Zhao, J.Y. Chen, L.J. Xu, T. Goedecke, X.Q. Zhang, J.A. Duan and C.T. Che, cis-Aconitic anhydride ethyl ester and phenolic compounds from the seeds of Alisma orientale. Nat. Prod. Comm. 7: 785-787, 2012.
  13. Y.F. Xian, Z. Lin, Q.Q. Mao, Z. Hu, M.H. Zhao, C.T. Che and P. S.P. Ip, Bioassay-guided isolation of neuroprotective compounds from Uncaria rhynchophylla against beta-amyloid-induced neurotoxicity. Evid.-based Complement. Alternat. Med. (eCAM), e802625, 2012.
  14. Y. He, Y.M. Zhang and C.T. Che, Chemical constituents in stems of Eurycorymbus cavaleriei. Zhongcaoyao 43: 1276-1279, 2012.
  15. M. Chen, F.W.K. Cheung, M.H. Chan, P.K. Hui, S.P. Ip, Y.H. Ling, C.T. Che and W.K. Liu, Protective roles of Cordyceps on lung fibrosis in cellular and rat models. J. Ethnopharmacol. 143: 448-454, 2012.
  16. M.L. Chen, L. Miao, J. Cao, S.P. Ip and C.T. Che, Quantitative analysis of biologically active ingredients of Five Seeds Combo by liquid chromatography-quadrupole time-of-flight mass spectrometry for quality control of commercial herbal product. J. Sep. Sci. 35: 1612-1618, 2012.
  17. H.W. Zhang, Y.F. Ho, C.T. Che, Z.X. Lin, C. Leung and L.S. Chan, Topical herbal application as an adjuvant treatment for chronic kidney disease - a systematic review of randomized controlled clinical trials. J. Adv. Nursing 68: 1679-1691, 2012.
  18. R. Feng, X. Zhou, P.M.Y. Or, J.Y. Ma, X.S. Tan, J. Fu, C. Ma, J.G. Shi, C.T. Che, Y. Wang and J.H.K. Yeung, Enzyme kinetic and molecular docking studies on the metabolic interactions of 1-hydroxy-2,3,5-trimethoxy-xanthone isolated from Halenia elliptica D. Don, with model probe substrates of human cytochrome P450 enzymes. Phytomedicine 19: 1125-1133, 2012.
  19. Q.-F. Hu, B. Zhou, X.-M. Gao, L.-Y. Yang, L.-D. Shu, Y. Shen, G.-P. Li, C.T. Che and G.-Y. Yang, Antiviral chromones from the stem of Cassia siamea. J. Nat. Prod. 75: 1909-1914, 2012.
  20. Q.-F. Hu, B. Zhou, J.-M. Huang, X.-M. Gao, G.-Y. Yang and C.T. Che, Antiviral Phenolic Compounds from Arundina gramnifolia. J. Nat. Prod. 76: 292-296, 2013.
  21. M. Zhao, T. Goedecke, J. Gunn, J.A. Duan, and C.T. Che, Protostane and Fusidane Triterpenes: A Mini-Review. Molecules 18: 4054-4080, 2013.
  22. C.T. Che, Z.J. Wang, C.W.K. Lam and M.S.S. Chow, Herb-herb combination for therapeutic enhancement and advancement: Theory, practice, and future perspectives. Molecules 18:  5125-5141, 2013.
  23. Q.-F. Hu, B. Zhou, J.-M. Huang, Z.-Y. Jiang, X.-Z. Huang, L.-Y. Yang,.X.-M. Gao, G.-Y. Yang,.and C.T. Che, Cytotoxic Oxepinochromenone and Flavonoids from the Flower Buds of Rosa rugosa. J. Nat. Prod. 76: 1866-1871, 2013.
  24. M. Zhao, X. Zhang, Y. Wang, M. Huang, J.-A. Duan, T. Gödecke, K.M. Szymulanska-Ramamurthy, Z. Yin and C.T. Che, Germacranes and m-Menthane from Illicium lanceolatum. Molecules 19: 4326-4337, 2014.
  25. C. M. Witt, M. Aickin, D. Cherkin, C.T. Che, C. Elder, A. Flower, R. Hammerschlag, J.-P. Liu, L. Lao, S. Phurrough, C. Ritenbaugh, L.H. Rubin, R. Schnyer, P.M. Wayne, S.R. Withers, Z.X. Bian, J. Young and B.M. Berman, Effectiveness guidance document (EGD) for Chinese medicine trials: A consensus document. Trials 15: 169, 2014. [DOI:10.1186/1745-6215-15-169]
  26. D.-T. Xie, Y.-Q. Wang, Y. Kang, Q.-F. Hu, N.-Y. Su, J.-M. Huang, C.T. Che and J.-X. Guo, Microwave- assisted extraction of bioactive alkaloids from Stephania sinica. Sep. Purif. Techol., 130: 173-181, 2014.
  27. F.W.K. Cheung, A.W.N. Leung, W.K. Liu and C.T. Che, Tyrosinase inhibitory activity of a glucosylated hydroxystilbene in mouse Melan-a melanocytes. J. Nat. Prod. 77: 1270-1274, 2014.

 

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