Karol S. Bruzik, Ph.D. DSc.Karol Bruzik

Professor and Associate Head for Curriculum
Department of Medicinal Chemistry and Pharmacognosy

University of Illinois at Chicago
College of Pharmacy
833 S. Wood Street (M/C 781)
Chicago, IL 60612-7231

Office: 527 PHARM
Office Phone: 312-996-4576
Fax Number: 312-996-7107
email address:


Technical University, Lodz, Poland MS 1967 - 1972
Polish Academy of Sciences, Poland Ph.D. 1974 - 1980
Ohio State University, Postdoctorial Fellow 1981-1983
Institute of Organic Chemistry, D.Sc. 1985 -1988

Research Interests:

Bioorganic chemistry. Mechanisms of phosphotransferases. Synthesis of biophosphate analogs as inhibitors and probes of enzyme mechanism. Isolation, structure determination and synthesis of novel phosphoinositides. Study and generalization of self-organization and phase behavior of amphiphilic molecules to develop new materials not found in nature.

POSITION AVAILABLE: Postdoctoral Research Associate(posted: 31-August-2009)


Professional Organizations:

Edited Journals and Honorarium:
Journal of American Chemistry Society
Journal of Organic Chemistry
Chemistry and Physics of Lipids
Bioorganic and Medicinal Chemistry
Nucleic Acid Research
Carbohydrate Research
Reviewer of grants for Petroleum Research Fund


MDCH 599
PHAR 331
PHAR 405
MDCH 571
MDCH 599
MDCH 460

Select Publications:

  1. Hondal RJ, Zhao Z, Kravchuk AV, Liao H, Riddle SR, Bruzik KS, Tsai MD. Mechanism of phospatidylinositol-specific phospholipase C: a unified view of the mechanism of catalysis. Biochemistry 1998;37:4568-4580.
  2. Nilius B, Prenen J, Voets T, Eggermont J, Bruzik KS, Shears SB, Droogmans G. Inhibition by inositol tetrakisphosphate of calcium- and volume-activated Cl-currents in endothelial cells. Pfluggers Arch Europ J Physiol 1998;435:637-644.
  3. Solomons KRH, Freeman S, Shears SB, Nelson D, Xie W, Bruzik KS, Kaetzel MA. Synthesis of d-1,2-dideoxy-1,2-difluoro-myo-inositol 3,4,5,6-tetrakisphosphate and its enantiomer as analogues of myo-inositol 3,4,5,6-tetrakisphosphate. Carbohydr Res 1998;309:337-343.